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谢克勤
17-11-27 09:41 toxicology  作者:毒理学系

 

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谢克勤,男,教授,博士生导师。山东大学公共卫生学院毒理学系主任、山东省高校毒理学重点实验室、山东大学新药评价中心、山东大学卫生分析测试中心主任。

学术简历

1982.12毕业于山东医学院公共卫生系获学士学位;1992.07毕业于山东医科大学毒理研究所获硕士学位;2001.07毕业于中国科技大学神经毒理实验室获博士学位;1991-1992年在英国Strathclyde大学生理药理系,访问学者;1999-2000年在美国Duke大学药理系神经毒理实验室,高级访问学者;2006.06-12月在美国Ohio州立大学分子神经生物中心,高级访问学者。

研究方向

环境污染物引起的神经退行性变。主要研究周围神经病变后神经丝及其它细胞骨架的改变,以及细胞信号网络、神经营养因子对细胞骨架在蛋白水平和基因水平的调控机制。

社会兼职

国家保健食品审评委员会审评专家;中国毒理学会理事;中国毒理学会神经毒理专业委员会副主任委员;中华预防医学会卫生毒理分会常务委员;中国毒理学会生化与分子毒理专业委员会常务委员;山东省毒理学会副主任委员;山东省预防医学会卫生毒理学分会副主任委员;《中华劳动卫生职业病杂志》编委;《毒理学杂志》编委;《山东大学学报(医学版)》常务编委;国际神经毒理学会会员

承担的主要研究课题

1.慢性正己烷中毒早期神经损伤的相关生物标志物研究(81373044)国家自然科学基金2014.1-2017.12

2.吡咯加合物作为慢性正己烷中毒早期神经损伤的生物标志物研究(20120131110058)教育部博士点基金2012.12-2016.12

3.正己烷引起中毒性周围神经病的分子机制研究(30872134)国家自然科学基金 2009.1-2011.12

4.血清神经丝ELISA法定量测定试剂盒的研制和应用(Z2007C06)山东省自然科学基金重点项目2007.122010.12

5.百合科葱属植物提取物对肝脏损伤的保护作用和产品开发(2008GG2NS02012)山东省科技攻关项目2009-2011

6.环境与健康--环境化学污染物对神经系统损伤及修复的机制研究(2002CB512907)国家科技部973课题2002-2008

主要学术论文(2010年—至今,均为通讯作者)

1.Han XY,Cheng D, Song FY, Zeng T, An LH, Xie KQ. Decelerated transport and itsmechanism of 2,5-hexanedione on middle-molecular-weight neurofilament in ratdorsal root ganglia cells.Neuroscience. 2014, 269:192-8.

2.Yin H,Zhang C, Guo Y, Shao X, Zeng T, Zhao X, Xie K. Biological exposure indices ofpyrrole adducts in serum and urine for hazard assessment of n-hexane exposure. PLoSOne. 2014, 9(1):e86108.

3.Song F, KouR, Zou C, Gao Y, Zeng T, Xie K.Involvement of autophagy intri-ortho-cresyl phosphate- induced delayed neuropathy in hens.NeurochemInt. 2014, 64:1-8.

4.Zeng T,Zhang CL, Song FY, Zhao XL, Xie KQ.CMZ reversed chronic ethanol-induceddisturbance of PPAR-αpossiblyby suppressing oxidative stress and PGC-1αacetylation, and activating the MAPK and GSK3βpathway. PLoSOne. 2014, 9(6):e98658.

5.Yin HY, GuoY, Song FY, Zeng T, Xie KQ. Toxicokinetic study of pyrrole adducts and itspotential application for biological monitoring of 2,5-hexanedione subacuteexposure.Int Arch Occup Environ Health. 2014, 87(6):655-62

6.Wang P, XieK, Wang C, Bi J.Oxidativestress induced by lipid peroxidation is related with inflammation ofdemyelination and neurodegeneration in multiple sclerosis.EurNeurol. 2014,72(3-4):249-54.

7.Zeng T,Zhang CL, Zhao XL, Xie KQ. Pentoxifylline for the treatment of nonalcoholicfatty liver disease: a meta-analysis of randomized double-blind,placebo-controlled studies. Eur J Gastroenterol Hepatol. 2014, 26(6):646-53.

8.Zeng T,Zhang CL, Song FY, Zhao XL, Yu LH, Zhu ZP, Xie KQ. The activation of HO-1/Nrf-2contributes to the protective effects of diallyl disulfide (DADS) againstethanol-induced oxidative stress. Biochim Biophys Acta, 2013, 1830: 4848-4859.

9.Yin H, GuoY, Zeng T, Zhao X, Xie K.Correlationbetween levels of 2, 5-hexanedione and pyrrole adducts in tissues of rats exposureto n-hexane for 5-days.PLoS One. 2013, 8(9):e76011

10.Zeng T,Zhang CL, Zhao XL, Xie KQ. The roles of garlic on the lipid parameters: asystematic review of the literature. Crit Rev Food Sci Nutr, 2013, 53: 215-230

11.Zeng T,Zhang CL, Han XY, Zhao S, Xie KQ. Association between CD14-159C>Tpolymorphisms and the risk for alcoholic liver disease: a meta-analysis. Eur JGastroenterol Hepatol, 2013, 25, 1183-1189.

12.Zeng T, LiY, Zhang CL, Yu LH, Zhu ZP, Zhao XL, Xie KQ. Garlic oil suppressed thehematological disorders induced by chemotherapy and radiotherapy intumor-bearing mice. J Food Sci, 2013, 78: H936-942.

13.Zeng T, GuoFF, Zhang CL, Song FY, Zhao XL, Xie KQ. Roles of Cytochrome P4502E1 GenePolymorphisms and the Risks of Alcoholic Liver Disease: A Meta-Analysis. PloSone, 2013, 8:e54188.

14.Zhang CL,Zeng T, Zhao XL, Xie KQ.Garlic oilattenuated nitrosodiethylamine-induced hepatocarcinogenesis by modulating themetabolic activation and detoxification enzymes.Int J Biol Sci.2013, 9(3):237-45.

15.Zeng T,Zhang CL, Song FY, Zhao XL, Yu LH, Zhu ZP, Xie KQ. PI3K/Akt pathway activationwas involved in acute ethanol-induced fatty liver in mice. Toxicology, 2012,296:56-66.

16.Zeng T,Zhang CL, Song FY, Zhao XL, Xie KQ. Garlic oil alleviated ethanol-induced fataccumulation via modulation of SREBP-1, PPAR-alpha, and CYP2E1. Food ChemToxicol, 2012, 50:485-491

17.Zeng T, GuoFF, Zhang CL, Song FY, Zhao XL, Xie KQ. A meta-analysis of randomized,double-blind, placebo-controlled trials for the effects of garlic on serumlipid profiles. J Sci Food Agric, 2012, 92:1892-1902

18.Song F, XieK.Calcium-dependentneutral cysteine protease and organophosphate-induced delayed neuropathy.ChemBiol Interact. 2012, 200(2-3):114-8

19.Song F,Zhang Q, Kou R, Zou C, Gao Y, Xie K.2,5-hexanedione altered thedegradation of low-molecular-weight neurofilament in rat nerve tissues.FoodChem Toxicol. 2012, 50(12):4277-84.

20.Song F, HanX, Zeng T, Zhang C, Zou C, Xie K.Changes in beclin-1 and micro-calpainexpression in tri-ortho-cresyl phosphate-induced delayed neuropathy.ToxicolLett. 2012, 210(3):276-84.

21.Song F, ZouC, Han X, Zeng T, Zhang C, Xie K.Reduction of retrograde axonaltransport associated-proteins motor proteins, dynein and dynactin in the spinalcord and cerebral cortex of hens by tri-ortho-cresyl phosphate (TOCP).NeurochemInt. 2012, 60(2):99-104.

22.Zhang CL,Zeng T, Zhao XL, Yu LH, Zhu ZP, Xie KQ. Protective effects of garlic oil onhepatocarcinoma induced by N-nitrosodiethylamine in rats.Int J Biol Sci. 2012,8 (3):363-74.

23.Wang Q,Song F, Zhang C, Zhao X, Zhu Z, Yu S, Xie K.Carboxyl-terminus of Hsc70interacting protein mediates 2,5-hexanedione-induced neurofilament medium chaindegradation.Biochem Pharmacol. 2011, 81(6):793-9.

24.Zeng T, XieKQ. The differential modulation on cytochrome P450 enzymes by garliccomponents. Food Reviews International.2010, 26(4):353-363.

代表性著作(章节)

1.谢克勤主编.酶组织化学与免疫组织化学原理和技术.山东大学出版社, 2014.3

2.牛侨主编.职业卫生与职业医学,人民卫生出版社,2013.1

3.王心如主编.毒理学基础,第六版.人民卫生出版社,2012.8

4.王心如主编.毒理学---实验方法与技术,第三版.人民卫生出版社,2012.8

5.王心如主编.毒理学基础,第五版.人民卫生出版社,2007.7

6.王心如主编.毒理学---实验方法与技术,第二版.人民卫生出版社,2007.8

重要奖项

1.ECPs致神经系统损伤及其防御的机制研究.山东省科技进步二等奖(第一位)2010

2.有机磷化合物引起迟发性神经病的机制研究.山东省科技进步二等奖(第一位)2008

3.有机磷化合物诱导母鸡迟发性神经毒性机制研究.山东省优秀博士论文指导教师2007

4.氯丙烯中毒性周围神经病轴浆内神经丝变性机制的研究.山东省科技进步三等奖(第一位)2005

5.Sepia对癌细胞Ras-MAPK信号传导系统和细胞骨架体系作用研究.山东省科技进步二等奖(第四位)2002

6.氯丙烯对神经系统毒作用研究.卫生部科技进步二等奖(第一位)1997

7.亲神经毒物烯丙基氯引起中毒性神经病发病机理的实验研究.国家教委科技进步二等奖(第一位)1996

8.用电生理和生化方法评价神经细胞毒性研究.山东省科技进步三等奖(第一位)1995

发明专利

1.大蒜油在抗辐射引起的白细胞减少和DNA损伤药物制备中的应用.中华人民共和国国家知识产权局;授权公告日:2006.5.17

大蒜油在制备抗急性酒精性脂肪肝药物中的应用.中华人民共和国国家知识产权局;授权公告日:2011.8.3

关闭窗口

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