旧版回顾 管理登录 English
当前位置: 网站首页 >> 专业机构 >> 流行病学系 >> 前沿进展 >> 国际进展 >> 正文

A method to estimate the size and characteristics of HIV-positive populations using an individual-based stochastic simulation model

时间:[2015-12-08]  来源:

Fumiyo Nakagawa, Ard van Sighem, Rodolphe Thiebaut, Colette Smith, Oliver Ratmann, Valentina Cambiano, Jan Albert, Andrew Amato-Gauci, Daniela Bezemer, Colin Campbell, Daniel Commenges, Martin Donoghoe, Deborah Ford, Roger Kouyos, Rebecca Lodwick, Jens Lundgren, Nikos Pantazis, Anastasia Pharris, Chantal Quinten, Claire Thorne, Giota Touloumi, Valerie Delpech, Andrew Phillips 

Epidemiology 2015 November 24

It is important not only to collect epidemiologic data on HIV, but to also fully utilize such information to understand the epidemic over time and to help inform and monitor the impact of policies and interventions. We describe and apply a novel method to estimate the size and characteristics of HIV-positive populations. The method was applied to data on men who have sex with men (MSM) living in the UK and to a pseudo dataset to assess performance for different data availability. The individual-based simulation model was calibrated using an Approximate Bayesian Computation-based approach. In 2013, 48,310 (90% plausibility range:39,900-45,560) MSM were estimated to be living with HIV in the UK, of whom 10,400 (6,160-17,350) were undiagnosed. There were an estimated 3,210 (1,730-5,350) infections per year on average between 2010 and 2013. 62% of the total HIV-positive population are thought to have viral load <500 copies/ml. In the pseudo epidemic example, HIV estimates have narrower plausibility ranges and are closer to the true number, the greater the data availability to calibrate the model. We demonstrate that our method can be applied to settings with less data, however plausibility ranges for estimates will be wider to reflect greater uncertainty of the data used to fit the model. 

上一条:中东呼吸综合征流行病学

下一条:Air Pollution, Cardiovascular Outcomes, and Social Disadvantage: The Multi-ethnic Study of Atherosclerosis

关闭窗口