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王志玉教授
18-03-17 09:37   作者:

 

说明:说明:王志玉

    名:

王志玉

    别:

    称:

教授(博士生导师,享受国务院政府特殊津贴)

    话:

0531-88382625

电子邮件:

Zhiyu.wang@sdu.edu.cn

通信地址:

济南市文化西路44

最高学位:

博士

 

学术简历:

1983毕业于山东医学院获学士学位,1986年毕业于山东医科大学获硕士学位,1993,91994,7美国麻省大学医学中心分子遗传学与微生物学系WHO高级访问学者,1996,91998,9美国麻省大学医学中心分子遗传学与微生物学系博士后研究, 2003年毕业于山东大学获博士学位。

研究方向:

          医学分子病毒学;病毒学检验

社会兼职:

中华预防医学会卫生检验学分会委员会副主任委员;全国高等学校卫生检验专业卫生部规划教材编写委员会委员;国家食品药品监督管理局保健食品审评专家;中华医学会医学病毒学分会委员会常务委员;山东省学校卫生协会副会长;山东预防医学会常务理事;山东微生物学会常务理事;山东省生物技术学会理事;山东省预防接种异常反应诊断小组成员;山东省艾滋病检测实验室评审专家组专家;山东省全球基金艾滋病项目专家组成员;《预防医学论坛》杂志副主编;《中国卫生检验杂志》常务编委;《病毒学报》编委;《国际病毒学杂志》编委;《中国病毒病杂志》编委等。

目前承担的主要研究课题:

          1.国家自然科学基金项目:副粘病毒HN蛋白功能性氨基酸定位与促细胞融合机制研究。 

2.山东省科技攻关项目风疹病毒基因工程亚单位疫苗的研究。

主要学术论文:

1.Zhao-Guo Wang,a,b Ying Yi,a Ting-Ting Yang,a Xiao-Lin Liu,a Fa-Chun Jiang,aZhi-Yu Wang,b Ji-MingChenEmergency surveillance of influenza during 2009 in the Chinese city of Qingdao. Influenza and Other Respiratory Viruses 520115359

2.Bing Wu, Xiaoli Liu,Zhiyu Wang. Effects of E2 and E1 Glycosylation on Specific Membrane Fusion in Rubella Virus Strain JR23. Intervirology, 2009, 52:68-77

3.Liu Xl, Wu B, Zhang Wq, Song Yy, Xu Hz, Wang Gt,Wang Zy. Effects Of Disulfide Bridges In Glycoprotein E1 On Fusogenic Activity Of Rubella Virus. Acta Virologica, 2009, 53(1): 29-34

4.Wenqiang Zhang, Guijie Ren, Bing Wu, Xiaoli Liu, Guiting Wang, Yanyan Song, Hongzhi Xu, Hongling Wen,Zhiyu Wang. Amino Acid Substitutions in Leucine Zipper Motif in the F-Specific Domain of Human Parainfluenza Virus 3 HN Protein Play Important Roles in the Protein Function. Intervirology, 2008, 51(5); 311-321

5.Guijie Ren,Zhiyu Wang, Xiaoyan Hu. Effects of Ectodomain Sequences between HR1 and HR2 of F1 Protein on the Specific Membrane Fusion in Paramyxoviruses. Intervirology2007, 50:115-122

6.Zexin Tao andZhiyu Wang. Sequence Analysis Of M Genome Segments Of Two Seoul Hantavirus Strains In Shandong, China. Acta Virologica, 2007, 51:67-68

7.Zexin Tao,Zhiyu Wang, Shaoxia Song, Hongling Wen, Guijie Ren, Guiting Wang. Genetic properties of medium (M) and small (S) genomic RNA segments of Seoul hantavirus isolated from Rattus norvegicus and antigenicity analysis of recombinant nucleocapsid protein. Virus Genes, 2007,34: 23-30

8.Guijie Ren,Zhiyu Wang, Guiting Wang, Yanyan Song, Ping Yao, Hongzhi Xu, Hongling Wen, Wenqiang Zhang. Effects of Heptad Repeat Regions of F Protein on the Specific Membrane Fusion in Paramyxoviruses. Intervirology, 2006, 49:299-306

9.Hongling Wen andZhiyu Wang. Expression and characterization of rubella virus glycoprotein E1 in yeast cells. Intervirology, 2005, 48(5):321-328

10.Zhiyu Wang, Anne M. Mirza, Jianrong Li, Paul J. Mahon and Ronald M. Iorio. An oligosaccharide at the C-terminus of the F-specific domain in the stalk of the human parainfluenza virus 3 hemagglutinin-neuraminidase modulates fusion.Virus Research, 2004, 99(2):177-185

11.Zhiyu Wang,Ping Yao, Yanyan Song, Guiting Wang, Yongkang Wang, Hongzhi Xu and Peng Wang. Characteristics and Mechanisms of Isolated Rubella Virus, Strain JR23: Infection of the Central Nervous System of BALB/c Mice.Intervirology, 2003, 46(2): 79-85

12.Zhiyu Wangand Ronald M. Iorio. Amino acid substitutions in a conserved region in the stalk of the Newcastle disease virus HN glycoprotein spike impair its neuraminidase activity in the globular domain.J Gen Virol,1999,80:749-75

13.Ruitang Deng,Zhiyu Wang,Paul J. Mahon, Mark Marinello, Anne Mirza, and Ronald M. Iorio. Mutations in the Newcastle disease virus hemagglutinin-neuraminidase protein that interfere with its ability to interact with the homologous F protein in the promotion of fusion.Virology,1999,253:43-54

14.Ruitang Deng,Zhiyu Wang, Anne A. Mirza, and Ronald M. Iorio. Localization of a Domain on the Paramyxovirus Attachment Protein Required for the Promotion of Cellular Fusion by its Homologous Fusion Protein Spike.Virology,1995,209(2):457-469

15.Ruitang Deng,Zhiyu Wang, Rhona L. Glickman, and Ronald M. Iorio. Glycosylation within an Antigenic Site on the HN Glycoprotein of Newcastle Disease Virus Interferes with its Role in the Promotion of Membrane Fusion.Virology,1994,204(1):17-26

16.WANG Zhiyu, XUE Yonglei, WANG Xiaofan, SONG Yanyan, WEN Hongling. Cloning and Sequence Analysis of Envelope Glycoprotein E1 Gene of Rubella Virus, JR23 Strain. Journal of Microbiology and Immunology, 2003, 1(1): 11-16

 

代表性著作(章节)

           《医学病毒学原理》,主编,中国医药科技出版社,1996

《病毒学检验》主编,人民卫生出版社,2006

重要奖项:

1.风疹病毒JR23株包膜糖蛋白的基因克隆与表达和功能分析,2006年获山东省科技进步奖,二等奖  

2.副粘病毒融合蛋白诱导细胞融合的分子机制,2010年获山东省科技进步奖,三等奖  

3.中枢神经系统风疹病毒感染的发生机理与防治对策的研究,2003年获山东省科技进步奖,三等奖

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